How do I use this tool?
GeneFriends is a functional genomics tool aimed at biologists and clinicians. It is based on a gene co-expression map that describes which genes tend to be activated (increase in expression) and deactivated (decrease in expression) simultaneously in a large number of human RNAseq data samples. Because the samples originate from a wide range of conditions, the co-expression map reflects which genes in general tend to be activated simultaneously and are thus under similar transcriptional regulation. This information can be used statistically, using a guilt-by-association approach, to identify and prioritize novel candidate genes involved in biological processes and complex diseases for which a seed list of genes associated with that disease or process is available. It can also be used to gain insights on genes of unknown function by looking at which genes they are co-expressed with. A detailed description of the RNAseq based version of GeneFriends will be available after publication. In the meantime please to refer to the about section and our previous publication on the microarray based co-expression map.
We constructed a co-expression map for humans. Other species may be added at later time points.
NOTE: The database behind the RNAseq based map is larger than 1 TB, for which reason some features may take up to a minute to load. We kindly ask you to be patient and not resubmit queries whilst the web page is loading.
Overall, GeneFriends can be used to:
- Assign putative functions to poorly annotated genes/features.
- Identify and rank new candidate genes/features related to a disease or biological process from a seed list of genes/features.
The microarray based version of this tool is also available